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MedpageToday

Navigating the Evolving Treatment Landscape of Diffuse Large B-Cell Lymphoma

<ѻý class="mpt-content-deck">– An ASCO Reading Room selection

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Medpage Today
Below is the abstract of the article. or on the link below.

Diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma, comprises a heterogenous group of morphologically, genetically, and clinically distinct diseases. Several recent advances have affected the treatment landscape, which had been mostly stagnant for the past few decades.

We will review the practice-changing studies in frontline (POLARIX), early relapse (ZUMA-7 and TRANSFORM), and multiple recurrent (ZUMA-1, JULIET, TRANSCEND, L-MIND, and LOTIS-2) stages and discuss how the treatment landscape may evolve with the emergence of bispecific antibodies.

We also highlight the rapidly evolving approaches available in later lines including clinical characteristics that may inform treatment selection, toxicity profiles, and sequencing of therapy.

Read an interview about the review here.

Read the full article

Navigating the Evolving Treatment Landscape of Diffuse Large B-Cell Lymphoma

Primary Source

Journal of Clinical Oncology

Source Reference:

ASCO Publications Corner

ASCO Publications Corner