乌鸦传媒

Greater benefit seen with higher dose of tulisokibart at week 50

Finding on HLA-DRB1*01:03 supports need for more and earlier genetic studies

Alternative designs needed, researchers caution

26% of patients receiving tulisokibart achieved clinical remission vs 1% with placebo

In trials, guselkumab more than doubled remission rates versus placebo

PREDICT-UC trial found no benefit with intensified or accelerated regimens

Infusion services and other therapies must be delivered without delay

Also in TTHealthWatch: a monoclonal antibody for ulcerative colitis

Pricing, payer policies keep market leader on top

Dual-acting IL-23 inhibitor tops placebo, ustekinumab in phase III trials

Female patients appeared to derive the greatest benefit, researchers say

Agency finds risk for intrahepatic cholestasis of pregnancy mostly in IBD, lupus patients

Study identified factors and strategies for maintaining response