乌鸦传媒

Genetics

<乌鸦传媒 class='mpt-top_cat_title_description'>News, opinions and meeting coverage in genetics.

ESC over a photo of ExCeL London conference and exhibition center.

<乌鸦传媒>Novel Drug Reduced Triglycerides, Risk of Pancreatitis in Persistent Chylomicronemia

Benefits seen in patients with and without a genetic diagnosis

A computer rendering of red blood cells

<乌鸦传媒>A Miss for Steroid-Toting Red Blood Cells in Ataxia Telangiectasia

Phase III trial falls short of efficacy target, but positive signal emerges in younger kids

FDA ADCOMM arimoclomol over a computer rendering of a strand of DNA.

<乌鸦传媒>FDA Advisors Mostly Convinced Arimoclomol Works for Rare Genetic Disorder

If approved, this would be the first drug for Niemann-Pick disease type C

FDA ADCOMM arimoclomol over a computer rendering of a strand of DNA.

<乌鸦传媒>FDA Panel to Consider Arimoclomol for Rare Genetic Disorder

This is the second time the drug has been submitted to the FDA for Niemann-Pick disease type C

A computer rendered strand of mRNA.

<乌鸦传媒>Gene-Expression Profiling Can Help Improve Outcomes in Cancers of Unknown Primary

In randomized study, guided site-specific therapy improved PFS versus empirical chemotherapy

A computer rendering of an artery, capillary, and arteriole.

<乌鸦传媒>Sotorasib Promising for KRAS鈥揜elated Vascular Malformations

Two patients had rapid symptom improvement and reductions in malformation volume

ASRS over a photo of Stockholmsm盲ssan Convention Center in Stockholm, Sweden.

<乌鸦传媒>Gene Therapies for Neovascular AMD Continue to Show Promise

Studies show 90% reduction in intravitreal treatment burden, durable effect on vision, anatomy

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

<乌鸦传媒>Trump's Former Doc Weighs In; 23andMe and Alzheimer's Risk; What's 'Teflon Flu'?

Health news and commentary gathered by 乌鸦传媒 staff

A photo of the East London skyline under a layer of smog.

<乌鸦传媒>Psoriasis Joins List of Diseases Tied to Air Pollution

Poor air quality adds significantly to risk from genetic susceptibility factors

A photo of smog over London.

<乌鸦传媒>Genes, Air Pollution Combine to Raise Lupus Risk

British data suggest how environmental and genetic factors add together

A computer rendering of an oligonucleotide aptamer attacking a cancer cell.

<乌鸦传媒>Can Oligonucleotide Infusions Really Fix Lyme, Cancer, and Other Diseases?

U.S. clinics market oligonucleotide therapy for a wide range of conditions, without much evidence

A photo of people on the beach in Tel Aviv, Israel.

<乌鸦传媒>Adolescent Obesity Tied to Parents' BMI at the Same Age

Moderate association between parental and offspring BMI at age 17

FDA APPROVED crovalimab (Piasky) over a computer rendering of blood flowing inside a vessel.

<乌鸦传媒>Subcutaneous C5 Inhibitor Approved for PNH

Longer-acting crovalimab designed for more sustained effect and less treatment burden

A computer rendering of a meningioma.

<乌鸦传媒>ALK Inhibitor Shows Promise in Rare, Progressive Tumor Types

Phase II study found brigatinib exceeded historical control by shrinking 10% of targeted tumors

A photo of Robin Alderman and her son Camden Alderman.

<乌鸦传媒>Gene Therapy May Cure More Rare Diseases, but Drugmakers Have Few Incentives

Profitability, production cost, and low number of patients are barriers

A computer rendering of amyloid plaques on a nerve cell

<乌鸦传媒>Alzheimer's Onset Delayed by Rare Mutation

Just one copy of the Christchurch variant conferred protection

computer rendering of amyloid plaques amongst neurons and neurofibrillary tangles inside neurons

<乌鸦传媒>Alzheimer's Risk Higher If Mom Had Memory Problems

Maternal history of memory impairment tied to higher amyloid burden

A microscope image of the 46 human chromosomes

<乌鸦传媒>A Single, Surprising Gene Behind a Disorder That Causes Intellectual Disability

Researchers estimate the disorder may affect as many as one in 20,000 young people

A photo of a man鈥檚 lip swollen from hereditary angioedema

<乌鸦传媒>Hereditary Angioedema Attacks Reduced With Donidalorsen Prophylaxis

Investigational treatment passes muster in phase III trial

A computer rendering of amyloid plaques amongst neurons and neurofibrillary tangles inside neurons.

<乌鸦传媒>Lifestyle-Dementia Links Persist Regardless of Risk Genes, French Study Shows

Dementia prevention efforts may be beneficial despite genetic susceptibility

A computer rendering of in vitro fertilization.

<乌鸦传媒>Fertility Treatment Safe for Breast Cancer Survivors With BRCA Mutations

No significant increased risk of recurrence or pregnancy complications

A computer rendering of rod and cone photoreceptors

<乌鸦传媒>Gene Editing Improves Vision in Rare and Devastating Retinal Disorder

Therapy improved best corrected visual acuity in four of 14 patients, and others benefited too

A computer rendering of amyloid plaques on a nerve cell.

<乌鸦传媒>Alzheimer's Variant May Cause Distinct Form of the Disease

Almost all APOE4 homozygotes develop Alzheimer's disease

A photo of a box of Adzynma

<乌鸦传媒>Impact of Recombinant Replacement Therapy Detailed in Genetic Clotting Disorder

Trial that led to FDA approval shows a big difference in replacement levels versus usual care

A computer rendering of a blood vessel narrowed by atherosclerosis

<乌鸦传媒>Age-Related Somatic Mutations Implicated in Cardiovascular Death

Clonal hematopoiesis a red flag for people with asymptomatic carotid atherosclerosis

FDA APPROVED mavorixafor (Xolremdi) over a photo of warts on a woman鈥檚 hand.

<乌鸦传媒>FDA Approves First Drug for WHIM Syndrome

CXCR4 antagonist mavorixafor effectively boosts neutrophils and lymphocytes to reduce infections

Stylized illustration of strands of human DNA.

<乌鸦传媒>Genetics Studies Have a Diversity Problem That Researchers Struggle to Fix

Most data based on DNA from white people, but small differences can have big health outcomes

A computer rendering of a motor neuron connecting to a muscle fiber.

<乌鸦传媒>Newborn Screening for SMA Appears to Offer Functional Benefits

German cohort study suggests earlier initiation of treatment benefits sitting, walking

A close up photo of a fitness tracker on a woman鈥檚 wrist reading 9,606 steps

<乌鸦传媒>Need 10,000 Daily Steps to Prevent Obesity? It May Depend on Genetics

Current recommendations may underestimate activity needs for people with high genetic risk

A photo of a vial of Fluorouracil

<乌鸦传媒>Overdosing on Chemo: A Common Gene Test Could Save Hundreds of Lives Each Year

Treatment can be deadly for enzyme-deficient patients; NCCN doesn't call for preemptive testing

FDA APPROVED ponatinib (Iclusig) over a computer rendering of the destruction of lymphoblast cells

<乌鸦传媒>FDA Approves New Frontline Regimen for Aggressive ALL

Ponatinib lands indication in combination with chemo for Philadelphia chromosome-positive cases

A photo of a physician performing a lumbar puncture

<乌鸦传媒>Spinal Delivery of Gene Therapy Promising for Neurodegenerative Disease

Early-phase clinical trial was suggestive of slower progression of giant axonal neuropathy

A computer rendering of prostate cancer.

<乌鸦传媒>Mutation Linked to Increased Risk of Prostate Cancer Mortality

Cancer-specific mortality twice as high in patients with specific genotype for HSD3B1 allele

A medical illustration of glaucoma.

<乌鸦传媒>Higher Polygenic Risk Score Tied to Increased Risk for Glaucoma

Risk scores may allow action before irreversible damage occurs in those with ocular hypertension

A photo of a female physician talking to her mature female patient in the MRI room.

<乌鸦传媒>Cancer Prevention Strategies Linked to Mortality Reduction in BRCA Carriers

Cohort studies indicate oophorectomy, breast MRI surveillance save lives, researchers say

AAAAI over a photo of Walter E. Washington Convention Center in Washington, DC

<乌鸦传媒>Oral Drug Gains Steam as On-Demand Option for Hereditary Angioedema Attacks

Investigational sebetralstat offered symptom relief in under 2 hours

A photo of Joni Rutter, PhD

<乌鸦传媒>Faster Cures, More Genetic Treatments: A Q&A With NIH's Joni Rutter

The NCATS Biomedical Data Translator is giving researchers ideas for new disease therapies

A computer rendering of a transparent body with the appendix highlighted

<乌鸦传媒>Potential Biomarker for Perforated Appendicitis Shows Link to Severe Sepsis

Test that can differentiate between simple and perforated appendicitis is "highly desirable"

SMFM over a photo of Gaylord National Resort & Convention Center in National Harbor, MD

<乌鸦传媒>Genome Sequencing Identified Variants in Fetal Structural Anomalies

Researcher touts identification of "high percentage of genetic disorders"

A photo of a woman receiving an ultrasound early in her pregnancy.

<乌鸦传媒>More Patients Rely on Early Prenatal Testing as States Toughen Abortion Laws

But testing early in pregnancy may be inaccurate

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